ERBB2 and neoplasm: Supporting the above results, significant correlations were found between the HER2-negative tissue status and the presence of tumor necrosis (p = 0.0012; OR = 7.16; 95% CI: 1.91-30.5), moderate malignancy grade (p = 0.049; OR = 3.4; 95% CI: 0.8-14.6), low Ki-67 values (p = 0.0022; OR = 6.42; 95% CI: 1.81-25.5) and ER positivity (p = 0.049; OR = 3.15; 95% CI: 0.91-11.45).