Second, miR-329 could directly regulate protein expression of c-Met by targeting the 3′-UTR of MET mRNA, and inhibit protein expression of cyclin D1 and gene expression of cyclin D1, cyclin D2, matrix metalloproteinase 7 (MMP-7) and MMP-9, while increase p57 and p21 gene expressions in lung cancer cell lines (A549 and H1299). The gene discussed is CCND1; the disease is lung cancer.