In our present study, we initially demonstrated that miR-329 promoted NSCLC cell (A549 and H1299) death, by targeting 3′-UTR of MET, inhibited the expression of anti-apoptotic protein Bcl2, and increased the expression of caspase-3 protein and increase of casepase-3/7 activities. This evidence concerns the gene BCL2 and non-small cell lung carcinoma.