CCL2 and Balkan nephropathy: A significant increase in serum creatinine was also evident on day 14 of untreated AAN, together with a substantial infiltrate of F4/80+ macrophages and CD3+ T cells (Figure 5B-5E) and up-regulation of MCP-1, TNFα, and MIF in both mRNA and protein levels (Figure 6D-6I).