Dual PI3K/mTOR inhibitors (BEZ235 or PI103) when combined with RT greatly improved treatment efficacy by repressing colony formation, inducing more apoptosis, leading to the arrest of the G2/M phase, increased double-strand break levels, and less inactivation of cell cycle check point, autophagy and NHEJ/ HR repair pathway proteins in PCa-radioresistant cells (161). This evidence concerns the gene MTOR and posterior cortical atrophy.