A-Nicastrin mice were born at Mendelian frequency, without gross developmental phenotype and unchanged body weight and adiposity with chow- (Supplemental Figure 4A, B) or HFD-feeding (Figure 5D–F), but in contrast to A-Rbpj mice, A-Nicastrin mice showed a trend towards reduced glucose intolerance and insulin sensitivity as compared to Cre- controls (Supplemental Figure 4C, G, H). The gene discussed is RBPJ; the disease is Glucose intolerance.