EDN1 and endothelial dysfunction: The suggested mechanisms of adriamycin-induced vasculopathy were endothelial dysfunction [15–18], suppression of endothelin-1 in endothelial cells [19], degeneration of endothelial structures [14], apoptosis of the endothelial cells [20], enhancement of procoagulant activity [21], smooth muscle dysfunction, and dysregulation of its calcium contents [10, 22].