HCAR1 and pancreatic neoplasm: The GPR81 receptor has been found in adipocytes (103), in the brain (104), in liver, skeletal muscle, and other human, mouse, and rat tissues (101); and more recently in colon, breast, lung, hepatocellular, salivary gland, cervical, and pancreatic carcinoma cell lines, as well as in tumors resected from patients with pancreatic cancer; in fact, 94% of the pancreatic tumors examined expressed high levels of GPR81 (105).