SLC16A1 and neuroblastoma: Lonidamine, an MCT inhibitor, induces an immediate decrease in intracellular pH in neuroblastoma cell lines (Sk-N-SH, CHP134, IMR32, and NGP), which correlates with diminished cell viability within 48 h of treatment (53); knockdown of MCT1, or inhibition of MCTs with the small molecule α-cyano-4-hydroxy-cinnamate, blocks cell proliferation, and migration, and induces apoptosis in glioblastoma cells (110–112).