IFIH1 and Candidemia: This finding was also validated on a functional level; patients with CMC express lower levels of IFIH1, there is a strong correlation between genetic variation in IFIH1 and candidemia, and cells from IFIH1 knock out mice and PBMC with different IFIH1 genotypes have altered cytokine production upon C. albicans stimulation (Jaeger et al., 2015).