TGFB1 and neoplasm: Using radio-labeled (89)Zr-conjugated fresolimumab for PET to analyze TGF-β expression, GC1008 accumulated in primary tumors and metastases in a manner similar to IgG, and (89) Zr-fresolimumab uptake is seen in sites of tumor ulceration and in scar tissue, where TGF-β is highly active (Oude Munnink et al., 2011).