Multitargeted receptor tyrosine kinase inhibitor Sorafenib, which has been approved for the treatment of advanced renal cell carcinoma and hepatocellular carcinoma (HCC), and Sunitinib, can improve experimental hepatic fibrosis, inflammation, and angiogenesis (Tugues et al., 2007; Mejias et al., 2009). The gene discussed is NTRK1; the disease is hepatocellular carcinoma.