KCNK2 and ischemia: TREK-1, the product of the kcnk2 gene, regulates cell excitability and prevents neuron death by inhibiting NMDA-dependent glutamatergic excitotoxicity induced by ischemia (Franks and Honore, 2004; Heurteaux et al., 2004; Buckler and Honore, 2005; Honore, 2007; Dedman et al., 2009).