A study of the protein changes in ACC in schizophrenia, MDD and bipolar disorder found that cytoskeletal and mitochondrial proteins are the most prominently altered in all of these disorders, but only 2 identified proteins (SRI, ALDOC) were found with changed levels in both schizophrenia and MDD (Beasley et al., 2006). Here, ALDOC is linked to major depressive disorder.