CPAP and microcephaly: Indeed, causal genetic defects for MCPH, such as MCPH1, CENPJ/CPAP, CEP213/CDK5RAP2, ASPM, WDR62, CEP135, CEP63 and STIL, encode centrosome or spindle-associated proteins, providing a further link between microcephaly and centrosomal-spindle function (11,12).