The increase of tumor volumes showed statistical significances with P<0.05 in 11 and 15 days, and P<0.01 in 18 and 21 days for shAnxa11-Hca-P-transplanted mice compared with scramble-Hca-P-transplanted mice due to Anxa11 downregulation (Figure 4A). This evidence concerns the gene ANXA11 and neoplasm.