Mice with a knockin of the cancer-associated MDM2 mutant, C305F (MDM2C305F), which fails to bind to L5 and L11, displayed a specific defect in p53 signaling in response to ribosomal stress, but not DNA damage, further validating the ribosomal stress-induced RPs-MDM2-p53 signaling pathway in vivo [25]. Here, TP53 is linked to cancer.