Multivariate Cox analysis showed that FHL1 expression (p = 0.021; HR 0.404, Cl, 0.187–0.871) together with lymph node metastasis (p = 0.017; HR 2.334, Cl, 1.167–4.671) was verified as independent predictors of OS and DFS in patients with HNSCC. This evidence concerns the gene FHL1 and head and neck squamous cell carcinoma.