After NHAs-RFP, NSCs-RFP and NSCs-BMP4-RFP were injected into the hemisphere directly contralateral to the GSC-GFP injection site for 14 days, we observed specific and appreciable engraftments of NSCs-BMP4-RFP and NSCs-RFP into malignant glioma. The gene discussed is BMP4; the disease is malignant glioma.