These biomarkers make up a diverse group of molecules with functional significance across various areas of tumour biology, including tissue metabolism (e.g., IGFBP1, leptin), immune response/inflammation (e.g., ICAM1, IL-10, IL-18BP, KIM1, MIP1A), signal transduction (e.g., AXL, HER2ECD), lymphangiogenesis (e.g., SVEGFR3), cell adhesion/extracellular matrix (e.g., FBLN1) and cell death (TRAIL-R3). The gene discussed is IGFBP1; the disease is neoplasm.