TRIM33 and chronic myelomonocytic leukemia: Mutations in epigenetic genes observed in almost every CMML case lead to DNA hypermethylation44 and epigenetically controlled changes in gene expression contribute to the disease phenotype, as demonstrated for transcription intermediary factor-1γ (TIF1γ) gene whose epigenetic downregulation was identified in a fraction of patients, and whose deletion in the myeloid compartment induces a CMML phenotype in the mouse45.