This IFN-response seems to be able to reduce, although not completely block, ANDV-replication as suggested by the decrease in ANDV S RNA and progeny virus titers observed from 15–20 days p.i. HPS patients show increased proinflammatory cytokine responses, which have been suggested to play a part in the pathogenesis [24–25, 32–33]. The gene discussed is IFNA1; the disease is Hermansky-Pudlak syndrome.