In particular, N-(MDA)-lysine adducts with UQCRC1 and ATP5B were found in AD brains at concentrations largely exceeding (>400%) those found in control brains, while only slight increases of the N-(MDA)-lysine adducts with HSP60 and no increases of the corresponding adducts with GDH1 were observed. The gene discussed is HSPD1; the disease is Alzheimer disease.