Specific HNE protein adducts have been identified by Li et al., who showed that HNE inhibited, by thiol-specific modification, the deacetylase activity of Sirtuin-3 (SIRT3), a major mitochondrial NAD+-dependent deacetylase, leading to increased angiogenesis and invasion of breast cancer cells [103]. This evidence concerns the gene SIRT3 and breast carcinoma.