Although the Hrh1 antagonist (terfenadine) did not affect AOM-DSS-induced colorectal carcinogenesis in mice, the Hrh2 antagonist (cimetidine) and Hrh3 antagonist/inverse agonist (clobenpropit) significantly inhibited AOM-DSS-induced colorectal carcinogenesis in mice. The gene discussed is HRH2; the disease is infectious otitis media.