In contrast, cleaved caspase-3 positivity (Figure 2B) in adenocarcinomas that developed in groups 3 (p < 0.001) and 4 (p < 0.001) was significantly higher than that of group 1, suggesting the induction of apoptosis by dietary Hrh2 and Hrh3 antagonists in the cancer cells. This evidence concerns the gene HRH3 and adenocarcinoma.