As noted in the case of cimetidine, a Hrh3 antagonist/Hrh4 agonist (clobenpropit) was able to inhibit AOM/DSS-induced murine colorectal carcinogenesis by modulating oxidative stress, the antioxidant status and the mRNA expression of certain inflammatory enzymes and cytokines. The gene discussed is HRH3; the disease is infectious otitis media.