HRH2 and adenocarcinoma: In contrast, cleaved caspase-3 positivity (Figure 2B) in adenocarcinomas that developed in groups 3 (p < 0.001) and 4 (p < 0.001) was significantly higher than that of group 1, suggesting the induction of apoptosis by dietary Hrh2 and Hrh3 antagonists in the cancer cells.