T-LAK-cell-originated protein kinase (TOPK), a novel mitogen-activated protein kinase kinase (MAPKK)-like serine/threonine kinase, is a member of the MAPKK family and is involved in many cellular functions, including the promotion of tumor development, regulation of cell growth, and inhibition of apoptosis [8,9,10,11,12,13]. This evidence concerns the gene PBK and neoplasm.