Cardiotoxicity (cardiac proliferation, -arteriopathy, -necrosis, -infarction and heart failure) was found to be significantly associated with the following altered genes: CA1, FOXP1, NOG, ABCG1, CD47, DOCK9, MARCH6, PDE7A, PRKCH BNIP3 and MIAT during radiation therapy. The gene discussed is PDE7A; the disease is heart failure.