Altered expression of AQP3, AAK1, BCL2, BIRC3, BNIP3, DDX17, FOXO1, ITPR1, MYC, PRKCA, SNCA, TNFRSF25, CCR7, MS4A1 and IMPDH2 was responsible for renal necrosis, nephrosis, nephritis, proliferation and kidney failure. The gene discussed is ITPR1; the disease is nephrosis.