We used an in silico approach to assess the methylation status of the promoter region on the TKTL1 gene in 385 metastatic melanoma tissues from the Skin Cutaneous Melanoma (SKCM) dataset of The Cancer Genome Atlas (TCGA) database (www.cbioportal.org) [40, 41] and estimated its association with TKTL1 mRNA expression. This evidence concerns the gene TKTL1 and metastatic melanoma.