MDMs that were transfected with control siRNA or with SULT1A1-siRNA#2 were challenged with the replication-competent CCR5-tropic HIV-1 Env + JM1186 virus encoding Renilla luciferase [34, 35] and luciferase expression was assayed three days post infection (Fig. 3a). The gene discussed is CCR5; the disease is infection.