Figures 6a and d show that tumor lysates from the METCAM clone 2D had a lower level of LDH-A than the control (vector) clone 3D, indicating that over-expression of METCAM/MUC18 decreased proliferation of SK-OV-3 cancer cells by decreasing aerobic glycolysis during in vivo tumorigenesis. This evidence concerns the gene MCAM and neoplasm.