To investigate if METCAM/MUC18-mediated tumor suppression also affected expression of its downstream effectors, such as indexes of apoptosis/anti-apoptosis, proliferation, survival, aerobic glycolysis, and angiogenesis, we determined the expression of levels of Bcl2, Bax, PCNA, LDH-A, VEGF, pan-AKT, phospho-AKT(Ser 473), and the ratio of phospho-AKT/AKT in tumor lysates. The gene discussed is PCNA; the disease is neoplasm.