Regardless, the role of METCAM/MUC18 as a tumor suppressor was not only conclusively demonstrated in a human ovarian cancer cell line, SK-OV-3 (as shown here), but also in another human ovarian cancer cell line BG-1 [Wu, unpublished results], as well as in a mouse melanoma cell line, K1735-9 [34] and one NPC cell line, NPC-TW01 ([35, 36], & Wu, unpublished results). This evidence concerns the gene MCAM and ovarian carcinoma.