To directly test the role of METCAM/MUC18 in the progression of epithelial ovarian cancer, we first chose to use SK-OV-3 cells for testing the effect of over-expression of METCAM/MUC18 on in vitro motility and invasiveness, in vivo tumor formation in nude mice after subcutaneous (SC) injection, and in vivo progression in nude mice after intraperitoneal (IP) injection. This evidence concerns the gene MCAM and ovarian carcinoma.