Taken together, we suggest that over expression of METCAM/MUC18 may suppress tumorigenesis and malignant progression of ovarian cancer cells in nude mice by decreasing their abilities in proliferation, aerobic glycolysis, and angiogenesis, and by decreasing motility and invasiveness, but not altering the apoptosis/anti-apoptosis and survival pathways. Here, MCAM is linked to ovarian cancer.