MCAM and neoplasm: One point worth noting is that the tumors induced by the METCAM clone 2D were confined to small regions, as shown in the results of H&E and IHC, whereas the tumors induced by the control (vector) clone 3D developed serious tumors, suggesting that tumors from the 2D clone appeared to be dormant; thus METCAM/MUC18 may function similarly to other tumor suppressors in other tumor cells [40].