By deducing knowledge learned from METCAM/MUC18-induced tumorigenesis of other tumor cell lines, such as, melanoma, cancers in breast and prostate and nasopharyngeal carcinoma, METCAM/MUC18 may affect tumorigenesis by cross-talk with many downstream signaling pathways that regulate proliferation, survival pathway, apoptosis, metabolism, and angiogenesis of tumor cells [7, 22–25]. Here, MCAM is linked to melanoma.