MCAM and neoplasm: To directly test the role of METCAM/MUC18 in the progression of epithelial ovarian cancer, we first chose to use SK-OV-3 cells for testing the effect of over-expression of METCAM/MUC18 on in vitro motility and invasiveness, in vivo tumor formation in nude mice after subcutaneous (SC) injection, and in vivo progression in nude mice after intraperitoneal (IP) injection.