Figures 6a and e show that tumor lysates from the METCAM clone 2D had a lower level of VEGF than the control (vector) clone 3D, indicating that over-expression of METCAM/MUC18 decreased proliferation of SK-OV-3 cancer cells by decreasing angiogenesis during in vivo tumorigenesis. The gene discussed is MCAM; the disease is cancer.