The regulation of DCNL activity in general appears to be important, as DCNL1 is highly amplified in various tumors where it acts as an oncogene (squamous-cell-carcinoma-related oncogene) (Broderick et al., 2010; Sarkaria et al., 2006) and DCNL5 (DCUN1D5) was also recently reported to be overexpressed in some oral and lung squamous cell carcinomas (Bommelje et al., 2014). The gene discussed is DCUN1D5; the disease is squamous cell lung carcinoma.