DCUN1D1 and squamous cell lung carcinoma: The regulation of DCNL activity in general appears to be important, as DCNL1 is highly amplified in various tumors where it acts as an oncogene (squamous-cell-carcinoma-related oncogene) (Broderick et al., 2010; Sarkaria et al., 2006) and DCNL5 (DCUN1D5) was also recently reported to be overexpressed in some oral and lung squamous cell carcinomas (Bommelje et al., 2014).