CCR5 is commonly expressed by intrathecal Th lymphocytes in both infectious (neuroborreliosis) and non-infectious (multiple sclerosis, MS) cns inflammation, usually alongside CXCR3 receptor for chemokines CXCL9 and CXCL10, but its role remains debatable [26, 28–30]. This evidence concerns the gene CCR5 and Lyme disease.