The CCR5 expression did not differ between the TBE patients and other groups, including healthy controls, did not differ between the subgroups of TBE patients, and did not change between examinations I, II, and III, but was highly individually variable with values in examinations I and II in the same patients correlated (correlation strength 0.6, p < 0.05). This evidence concerns the gene CCR5 and tick-borne encephalitis.