APC and cancer: The Wnt family of secreted proteins fulfills key evolutionarily conserved functions in normal development and adult tissue maintenance10, 11, 12, 13 and its deregulation by alteration of expression or mutation of its key components including β−catenin, adenomateous polyposis coli (APC) and AXIN, is associated with development and progression of diverse cancer types13, 14, 15, 16, 17, 18.