PDE10A and Behcet disease: Our prior case–control study of 29 different genes comprising the cAMP signaling pathway identified seven common and eight rare nucleotide variants associated with BD that mapped to a 23 kb intronic region of the PDE10A gene.12 Importantly, the rare variants that we identified have not yet been discovered in any of the ongoing genome-sequencing projects, adding weight to the possibility that they are causally associated with BD.