It has been proposed that this mechanism contributes to the clinical benefit of antipsychotic treatment by normalizing glutamate hypofunction in schizophrenia.65, 66 Given what we know about the importance of functional GluD2 for APMA activity, our findings provide an important basis for future studies investigating GluD2 and the mechanism of treatment response. This evidence concerns the gene GLUD2 and schizophrenia.