GLUD2 and schizophrenia: GRID2 is noted to be associated with neurocognitive endophenotypes including prepulse inhibition, startle habituation, P50 suppression, verbal learning and executive function tasks.7, 8 In addition, our most significant SNP, rs1875705, was nominally associated with schizophrenia is the Psychiatric Genomics Consortium's mega-analysis.6 New evidence linking GRID2 deletion with altered response to the NMDA receptor antagonist memantine further supports the importance of intact GluD2 function for optimal glutamate signaling.67