The analysis of the distribution of the EPIYA patterns in monoinfected patients showed that colonization by H. pylori CagA-positive with two or three EPIYA C motifs was more prevalent among patients with gastric adenocarcinoma (OR = 3.78, 95% IC (1.92–7.46), P = 0.002). The gene discussed is S100A8; the disease is gastric adenocarcinoma.