TTR and osteomyelitis: Amyloidosis is classified based on clinical features into (a) primary AL amyloidosis, which may be associated with plasma cell disorders including MGUS as in our patient; (b) secondary AA amyloidosis, which occurs in the setting of chronic inflammation or infection such as rheumatoid arthritis and osteomyelitis; (c) familial AF amyloidosis, which is most commonly due to mutations in the transthyretin, a transport protein; and (d) senile amyloidosis.3 Amyloidosis can affect many organs, with the most common ones being kidneys, heart, nerves, and gastrointestinal tract.