TNF and thrombophilia: Many factors such as histamine, bradykinin, tumor necrosis factor-α, interleukin-1, fibrinogen degradation product, thrombin, and platelet activating factor are involved in hypercoagulability in acute pancreatitis due to hypertriglyceridemia.8 A simple PE was used to treat the patient, and blood cell and serum components were separated using a membrane plasma separator.