In another murine model of GN induced by a planted foreign antigen (sheep globulin) against the glomerular basement membrane (GBM), our group reported that MPO−/− mice are protected from renal injury in the initial (heterologous) phase of the disease [56] which is mediated by neutrophils but is independent of T cells [108], showing that neutrophil-derived MPO contributes to kidney damage locally. The gene discussed is MPO; the disease is ganglioneuroma.