Therefore, under the aforementioned combinatorial perturbation, components involved in cell proliferation were downregulated through the inactivation of PI3K, and the activity of tumor-suppressor genes (PLA2) with arachidonic acid (AA) and other components, including Ca, CaM, and CaMK, was increased as a result of the IP3R1 overactivation. Here, PIK3CA is linked to neoplasm.