RYR2 and hypertensive disorder: On the contrary, in hypertensive subjects we found a higher, statistically significant frequency of RyR2 QQ genotype among VT/VF patients (p = 0.0001 with Fisher's exact test and p = 0.004 using Armitage trend test), which was associated with an increased risk of malignant ventricular arrhythmias (RR 2.51; IC 95% 1.96–3.23; p = 0.0001), whereas in hypertension-free patients the genotypic percentages were the same in the two groups (p = 1).