The comparison among urinary levels of the evaluated markers and parameters such as age, BMI, duration of disease, and renal function indexes allowed us to detect significant relationships in T2DM patients among NGAL levels and both NAG (r = 0.606, p < 0.0001) and the presence of hypertension (r = 0.352, p < 0.05). The gene discussed is LCN2; the disease is type 2 diabetes mellitus.