We have demonstrated the protective role of GA against sepsis-induced AKI by alleviating the pathological damage of kidney tissue, inhibiting the release of inflammatory cytokines and mediators, suppressing the kidney cells apoptosis, and inactivating NF-κB. Our study indicates that treatment with GA might be a potential approach in the treatment of sepsis-induced AKI. Here, NFKB1 is linked to acute kidney injury.