Adipocytes produce a variety of molecules biologically active including interleukins, tumor necrosis factor-alpha (TNF-α), resistin, leptin, adiponectin, monocyte chemoattractant protein- (MCP-) 1, transforming growth factor- (TGF-) β, insulin-like growth factor- (IGF-) 1, and C-reactive protein (CRP); a deregulated production of these factors is involved in the systemic inflammatory process occurring in obesity [2, 3]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.