MiR-21 is upregulated in a variety of CNS tumors, possibly because of its role in targeting tumor suppressors Acidic Nuclear Phosphoprotein 32 Family, Member A (ANP32A) and SWI/SNF-related, Matrix-associated, Actin-dependent Regulator Chromatin group A (SMARCA4) (Akers et al., 2013). The gene discussed is SMARCA4; the disease is central nervous system neoplasm.