Genetic susceptibility for SLE includes genes encoding (1) components of pathways upstream and downstream of type I IFN, such as components of TLR and IFN signaling pathways, (2) intracellular DNA degradation, and (3) autophagy-related genes, which might all foster IFN-α production by pDC (125). This evidence concerns the gene IFNA1 and systemic lupus erythematosus.