In addition, predicted metabolic capacity of bacterial community (generated using PICRUSt) exhibited increased abundances of genes associated with glycerolipid metabolism with HMW β-glucan diet compared to control and LMW β-glucan diets, which has been associated with obesity and type 2 diabetes via energy homeostasis, appetite control, and insulin sensitivity (Prentki and Madiraju, 2008). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.