Peripheral blood mononuclear cells (PBMCs) isolated from patients with cryptococcal meningitis exhibited a significant reduction in TLR2 expression compared to healthy control PBMCs and blocking TLR2 on PBMCs led to a reduction in IL-12p70 and IFN-γ when stimulated with Cryptococcus (Zhang et al., 2015a). This evidence concerns the gene IFNG and Cryptococcal meningitis.