Dectin-1 has been shown to bind to the β-glucans found on cryptococcal spores (Giles et al., 2009), however, there was no significant difference in disease progression in Dectin-1 KO mice compared to WT mice during cryptococcal infection indicating that Dectin-1 may not be required for host defense to C. neoformans (Nakamura et al., 2007). This evidence concerns the gene CLEC7A and cryptococcosis.