The documented molecular network variation studies between NFPAs versus controls (6, 20), invasive and non-invasive NFPAs (14), and four NFPA subtypes (NF−, LH+, FSH+, and LH/FSH+) subtypes (1) should be extended to other NFPA subtypes, such as silent ACTH- and GH-positive NFPAs, and different FPA subtypes, such as ACTH-, TSH-, GH-, and PRL-cell FPAs (5). This evidence concerns the gene POMC and non-functioning pituitary adenoma.