Since AKAP-PKA interactions are involved in AQP2 trafficking (Klussmann et al., 1999; Klussmann and Rosenthal, 2001), their disruption may lead to a new concept for the treatment of diseases characterized by excessive AVP-mediated water retention such as heart failure (Nedvetsky et al., 2009; Tröger et al., 2012; Deak and Klussmann, 2015; Dema et al., 2015). The gene discussed is AVP; the disease is heart failure.