Although neurofibrillary tangles (tau pathology) and tau-related neurodegeneration are considered the next stage of the AD progression (Jack et al., 2013), cortical Aβ-negative individuals can also have neurodegeneration (as tracked by tau biomarkers; Dickerson and Wolk, 2012; Crary et al., 2014; Kovacs et al., 2016). The gene discussed is MAPT; the disease is Alzheimer disease.