Additionally, research has long supported the notion that tau is the major component of neurofibrillary tangles that positively and robustly correlate with AD severity Grundke-Iqbal et al., 1986; Nukina and Ihara, 1986; Kondo et al., 1988; Kosik et al., 1988; Braak and Braak, 1991; Götz et al., 2001; Lewis et al., 2001). The gene discussed is MAPT; the disease is Alzheimer disease.