CS is a rare endocrine disorder (1.2–2.4/million/year) characterized by chronic excess endogenous GCs due to an ACTH pituitary adenoma or a cortisol-producing adrenal adenoma (Lacroix et al., 2015); left untreated, CS results in increased mortality and multiple morbidities including obesity, diabetes, hypertension, cardiovascular disease, and overall lower health-related quality of life (Webb et al., 2008; Feelders et al., 2012; Carluccio et al., 2015). This evidence concerns the gene POMC and Cowden syndrome 1.