The role of PTX3 in inflammatory processes has been confirmed by in vitro studies on cultures of smooth muscle cells from healthy human arteries incubated with modified atherogenic lipoproteins [4]. In vivo studies have found a relationship between the cells of carotid atherosclerotic plaques and myocytes of patients with acute myocardial infarction with high levels of PTX3 [5–7]. This evidence concerns the gene PTX3 and acute myocardial infarction.